Physiology 4600A/B Lecture Notes - Lecture 2: Ligand-Gated Ion Channel, Bicuculline, Receptor Antagonist
22 Apr 2019
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Gaba is the most common inhibitory neurotransmitter in the cortex. We usually measure the action of gaba looking postsynaptically or by looking at ipsps. Whether it has this late component present depends on whether it has gabab present or not. Gabab receptors aren"t that many so even when they are open they don"t have a huge amount of: so theres not that many of them but they are there and can repress some long term conductance events. Different experimental approaches are used to study epilepsy and seizures. In vivo: in animals, using induced seizures or epilepsy in animals. Ach can induce seizures by increasing ach conc in the brain (this is not used commonly to induce seizures though: k+ channel antagonist, 4-aminopyridine. Repeated electrical/chemical stimulation: ex: chemical stimulation - give one a very lose dose of nmda agonist to the animal and keep repeatedly doing that, ex: electrical stimulation (kindling model)
