Physiology 3140A Lecture Notes - Lecture 5: Squamous Cell Carcinoma, Desmoplakin, Vimentin

• School: Western University
• Department: Physiology
• Course: Physiology 3140A
• Professor: John Di Guglielmo

Document Summary

Heterophilic binding: cell-matrix: integrins bind different molecule in ecm (in this case fibronectin, cell-cell: selectin on one cell membrane binds to glycoprotein on other cell lectins bind sugars. E-cadherin (epithelial cadherins) bind identical e-cadherin on other cell. Binding affinity: how well proteins on one cell can interact with proteins on another cell, can change depending on extracellular fluid content (e. g. ca2+ presence) Spatial distribution: number of junctions, many, many proteins come together and zipper up" to create a tight bond. These factors can change the activity state of a cam and its ability to bind another protein. *indication of spatial distribution (more proteins = stronger bond) 3 types of cell junctions: anchoring junctions, occluding junctions (tight junctions, communicating junctions (gap junctions) Mechanically attach cells to neighboring cells or ecm. Cell-matrix: hemidesmosomes (intermediate filaments, focal adhesions (actin) Cell-cell: adherens junctions (actin) e. g. e-cadherin, desmosomes (intermediate filaments) Cadherin family members with desmo" prefix e. g. desmoglein, desmocollin etc.