Pharmacology 3620 Lecture Notes - Lecture 22: Grin2B, Olanzapine, Risperidone

• School: Western University
• Department: Pharmacology
• Course: Pharmacology 3620
• Professor: Rommel Tirona

Document Summary

Dementia: loss of cognitive and executive function. 10% ad + vascular (i. e. microvascular damage) 7% lewy bodies (protein aggregates; dis(cid:272)ussed i(cid:374) (cid:373)otor disorder"s lecture) (cid:1009)% vas(cid:272)ular or (cid:862)ad + le(cid:449)y (cid:271)ody(cid:863) Women are at higher risk than men slightly. This is a problem with the aging population because a large portion of them will suffer from dementia. Fi(cid:374)di(cid:374)g (cid:449)ay arou(cid:374)d (cid:894)e. g. (cid:272)a(cid:374)"t fi(cid:374)d (cid:449)ay ho(cid:373)e fro(cid:373) the gro(cid:272)ery store(cid:895) Measured by mini state of mental examination (mmse) scores; can be done in 10-15 minutes: the diagnostic cut off is a score of 30. As the score decreases, the symptoms worsen: mood & behavioural problems = cranky & loss of sense of humour, loss of fu(cid:374)(cid:272)tio(cid:374)al i(cid:374)depe(cid:374)de(cid:374)(cid:272)e = (cid:272)a(cid:374)"t go places alone, nursi(cid:374)g ho(cid:373)e pla(cid:272)e(cid:373)e(cid:374)t = ca(cid:374)"t take (cid:272)are of themselves. . 9 billion a year in canada in 1994. Us = 18 million people over the next 50 years will have ad; cost estimates are up to billion/year in us.