Pharmacology 3620 Lecture Notes - Lecture 9: Wild Type, Methyl Group, Racemic Mixture

• School: Western University
• Department: Pharmacology
• Course: Pharmacology 3620
• Professor: Rommel Tirona

Document Summary

Feel free to email me (oneclass512475@gmail. com) if you have any questions or don"t understand something! Precision medicine: a(cid:374) e(cid:373)e(cid:396)gi(cid:374)g app(cid:396)oa(cid:272)h fo(cid:396) disease p(cid:396)e(cid:448)e(cid:374)tio(cid:374) a(cid:374)d t(cid:396)eat(cid:373)e(cid:374)t that takes i(cid:374)to a(cid:272)(cid:272)ou(cid:374)t people"s individual variations in genes, environment and lifestyle. Cyp2d6 metabolizes approximately 25% of all drugs on the market. Variable response was originally described by two independent laboratories at the same time. Cyp2d6 is one of the prototypical examples in pharmacogenetics as there exists snps, ins/dels and copy number variations. There are over 90 known allelic variants in cyp2d6. Debrisoquine is an example of a drug impacted by cyp2d6. Nomenclature: polymorphisms in drug metabolizing enzymes like cyp(cid:1006)d(cid:1010) a(cid:396)e ofte(cid:374) (cid:396)efe(cid:396)(cid:396)ed to (cid:271)(cid:455) the (cid:862)*(cid:863) nomenclature, for example, cyp2d6*1 represents the wild-type sequence whereas cyp2d6*3 has an a2367del, the star nomenclature often represents more than one polymorphism. A person"s highest functioning cyp2d6 allele predicts their cyp2d6 phenotype. Whe(cid:396)e (cid:862)mr(cid:863) = debrisoquine: 4-oh debrisoquine urinary ratio.