Pharmacology 3620 Lecture Notes - Lecture 2: Ascites, Xenobiotic, Lipophilicity

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Define bioavailability and first-pass effect as it pertains to drug absorption. Absorption is the transfer of drug from its site of administration to the bloodstream (systemic circulation) Oral drug administration is the most common route of administration and thus the extent of intestinal drug absorption impacts the dose of many drugs. Drugs that are administered intravenously are considered to be entirely absorbed into the bloodstream. That is, the dose of iv drug is equal to the amount that gets in the body. Bioavailability (f) the proportion of drug dose which reaches the systemic circulation in an unaltered form after drug is administered bioavailability of a drug is often presented as % of the dose. Major determinant of bioavailability a drug can be metabolized by the gut and the liver during the initial absorption of an oral dose before it reaches the system circulation.

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