Pharmacology 2060A/B Lecture Notes - Lecture 5: Renal Blood Flow, Renal Function, Renal Cortex
20 Apr 2021
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Is the removal of parent drug and drug metabolites from the body. Sites of drug excretion: kidney, bile, lung, breast milk. The kidneys account for the majority of drug excretion. Healthy kidneys serve to limit the duration and intensity of drug effects. Has an outer cortex and an inner medulla. The functional region of kidney, nephron, spans from renal cortex into medulla. The basic structural and functional unit of the kidney. Controls blood volume, blood pressure, blood ph and solute (including drug) excretion. 5. 2 factors a ecting renal drug excretion: glomerular filtration, tubular secretion, tubular reabsorption. **note: gaining a thorough understanding of the kidney here will make module 13 much easier. Drugs enter the kidney from the renal artery. Hydrostatic pressure within glomerular capillaries forces low molecular weight drugs into the renal tubules. Glomerular filtration rate is ~ 120 ml/min/1. 73 m2 or about 20% of total renal plasma flow. Lipid solubility and ph do not affect glomerular filtration of drugs.
