Pharmacology 2060A/B Lecture Notes - Insulin Receptor, Gaba Receptor, Pharmacodynamics
3 Mar 2014
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Called the ed50: drugs with lower ed50 are said to be more potent than a drug with a high ed50. 7. 3 drug receptors how do drugs produce effects: most drugs act on cellular macromolecules (receptors, enzymes, etc) Majority are targeted to enzymes, but some act on receptors, ion channels, etc: typical drug action involves binding of drug to macromolecule target. The complex is then able to produce a biological effect: drugs typically mimic an endogenous compound in the body. Norepinephrine binds to receptors on heart and increases heart rate: drugs that mimic ne bind same type of receptor, do all drugs act on cellular targets, no, most drugs act on cellular targets, best example antacids. Drugs that neutralize stomach acid to provide symptomatic relief of gi disorders. Simply bases that neutralize stomach acids don"t bind any cellular target: types of drug receptors, receptor: protein that drug binds and produces a measurable response.
