Pharmacology 2060A/B Lecture Notes - Lecture 3: Plasma Protein Binding, Body Water, Extracellular Fluid
24 Oct 2018
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Document Summary
Drugs distribute into compartments in the body where they may be stored, metabolized, excreted or exert their pharmacological effect. The body"s compartments include: water soluble drugs distribute in the interstitial space. Interstitial space the extracellular fluid that surrounds cells. Total body water includes the fluid in the interstitial space, intracellular fluid and the. Plasma the non-cell containing component of blood. Muscle some drugs bind tightly to muscle tissue. Bone some drugs adsorb onto the crystal surface of bone with eventual incorporation into the crystal lattice. Bone can be a reservoir for the slow release of some drugs. Other tissues protein and high molecular weight drugs typically distribute in plasma. plasma. tissue. Drug distribution is determined by: blood flow to tissues, ability of drug to move out of capillaries, ability of drug to move into cells. The more drug that distributes out of the blood compartment, the lower the concentration of drug in the blood: blood flow to tissues.
