Pharmacology 2060A/B Lecture Notes - Lecture 2: Hydrophile, Asthma, Venous Blood
22 Mar 2018
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Document Summary
Pharmacokinetics is defined as the study of drug movement in the body, composed of 4 basic processes (adme: absorption, distribution, metabolism, excretion) Absorption: drug absorption is the movement of the drug from the site of administration into the blood, absorption rate determines how quickly the drug effect will occur; absorption amount determines how intense the drug effect will be. Factors of absorption: rate of dissolution, dissolving in solution (drugs must dissolve before they can be absorbed) Faster rate of dissolution = faster onset of action. Surface area : major determinant of drug absorption. Once the drug passes into the more alkaline intestine, the enteric coating dissolves: bioavailability, the fraction of a dose of drug that reaches the systemic circulation unchanged. Iv drugs can be given as a bolus, where a single dose is administered over a short time over a prolonged period: drugs are typically diluted in a "vehicle, ex. saline in an iv bag.
