Pharmacology 2060A/B Lecture 11: Module 11 Study Notes – Pharmacotherapeutics
13 Sep 2017
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Module 11 study notes pharmacotherapeutics: medication misadventures. Drug interaction with other drugs or components in our diet can produce complicated responses. Drug-drug interactions may occur when a patient takes two or more drugs at the same time. Drug-food interactions may occur even if a patient is only taking one drug. Risk of drug interactions increases with the number of medications a patient takes (almost linearly) Drug interactions are especially important in the elderly: average 65-year-old takes 7 medications, significantly more than the average 20-year-old. Most common type of drug-drug interactions are those that affect pharmacokinetics (adme) 3 possible outcomes for when two or more drugs interact: increased effects: Drug interactions can increase drug effect by: Ampicillin is an antibiotic that is rapidly inactivated by bacterial enzymes making it ineffective at killing bacteria. Sulbactam is an inhibitor of the bacterial enzyme that inactivates ampicillin. Ampicillin + sulbactam increased therapeutic activity of ampicillin. Of increasing the therapeutic effect with a drug interaction.
