Pharmacology 2060A/B Lecture Notes - Lecture 9: Cirrhosis, Cytochrome P450, Adverse Drug Reaction
13 Sep 2017
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Module 9 study notes pharmacodynamics: therapeutic index. Ideal: responses to medications would be the same for every patient. Reality: variability of responses between patients is common. Because responses are variable eve(cid:396)y patie(cid:374)t"s (cid:396)espo(cid:374)se (cid:373)ust (cid:271)e evaluated to e(cid:374)su(cid:396)e ade(cid:395)uate therapeutic response. Responses to medication is influenced by: genetics, disease state, environment. Clinical trials are the important first step in determining variability between patients with drug response. How variable the plasma concentrations of the drug will be. 300 500 patients with the disorder. Short term trial to determine efficacy and side effects. 500 5000 patients with the target disorder. Efficacy verified and long-term side effects evaluated. Phase ii clinical trials establish dose- response information over a range of doses. Determining interpatient variability in response to medications: set an end point, an end point is a goal for the therapeutic response, ex.
