Pathology 3500 Lecture Notes - Lecture 22: Epiphysis, Hyaline Cartilage, Chondrocyte

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Normal classification: bony joints (skull sutures, fibrous joints (pubis symphysis, cartilaginous joints - most joints in our body, hip bone, knee, etc. Function: cartilage is firm yet pliable and changes shape under increasing loads. Surfaces of joint come into increasing contact thereby distributing the load: cartilage is also elastic by extracellular matrix which retains water. Upon removal of the force the extracellular matrix draws the water back in and the cartilage recovers its original shape: cartilage is avascular, receives all nourishment from synovial fluid. 2) freedom of opposed articular surfaces to move over one another. 3) correct distribution of load across joint tissues in order to avoid damage. Disease: arthritis (common, non-inflam: osteoarthrisitis, inflam: infections, infections, tumours. Gross features: articular surface and bone are misshapen. Rather than being smooth, pearly-blue, and shiny, the articular cartilage will show areas of thinning, roughening (fibrillation), red-brown discoloration, and often areas of. *subchondral bone sclerosis and subchondral cysts may be identified.

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