Pathology 3500 Lecture Notes - Lecture 1: Human Papillomavirus Infection, Cervical Cancer, Neoplasm
23 Jan 2020
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Document Summary
Vulvar disease: skin so there are lots of dermalogic conditions. Hpv (human papilloma virus: sti which infects squamous cells (sexually transmitted) low risk strains: results in genital warts, condyloma, high risk strains: pre cancerous changes (can get into genome and mutate) Risk factors: beh"r based: intercourse, multiple partners, smoking, biological: host factors (immune response), viral factors, weakened immune. Some patients are more a risk than others. Vulvar condyloma accuminatum: genital warts (hpv-6/11, cells invade epidermal cells and replicate, weird nucleus with white around it, epidermis looks more thick. Vulvar intraepithelial neoplasia (vin: mostly squamous cell carcinoma. Hpv associated (high risk viral strains: younger age, multifocal disease. Lost of growth regulation, full maturity of cells, thickness (enough mutations will occur and will penetrate and spread) becomes cancer. Transformation zone: where squamous and columnar epithelium (there is active metaplasia) Hpv likes to infect meaplastic cells cause its still immature and susceptible to infection.
