Microbiology and Immunology 3820A Lecture Notes - Lecture 4: Phagocyte, Fragment Crystallizable Region, Mucosa-Associated Lymphoid Tissue

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Primary response generates effector cells and memory cells: daughter cells are going to become either effector cells (plasma cells) or remain as a memory b cell. 2: plasma cells secrete antibodies, b cell immunity is least understood, used to barely be able to tell the memory or plasma cell apart by appearance. If b cell does not bind its antigen, it remains inactive & re-circulates. 5 classes of ig molecules, also called isotypes (important: class is defined by differences in heavy chain constant region, heavy chains shown in different colours in picture above, length, distribution of carbohydrates, location of hinges (joining the chains) If no hinges then its more rigid: more hinges give flexibility to reach out and grab epitope, better binding with more hinges. Most common b cell response is against protein antigens: respond to protein and non protein antigen, protein antigen on the surface(protein antigen on an extracellular pathogen, or soluble protein such as allergens.

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