Microbiology and Immunology 3820A Lecture Notes - Lecture 12: Rhinovirus, Common Cold, Myalgia
9 Dec 2016
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Document Summary
Helical (straight rod), enveleloped, naked (circle) spaceship. Require host cell machinery to facilitate disease. Cannot replicate outside of a host cell. All information for viruses is contained in the genome. Cause of about 80% of acute illnesses that result in a loss of time from work. 80% of all respirator infections are viral. Aroudn fiftieth week of year is when we gt a surge of infections. Circulates in three type a, b, c. B and c only infect humans and never caused pandemics. Influenza a naturally found in water foul, but can infect human, swine, poultry ect. Ha (15 types): binds to oligosaccharides on cell surface containing terminal sialic acids. Na (9 types): cleaves sialic acid groups upon viral entry/exit (tamiflu) M2: essential for virus uncoating during viral entry. Many antivirals are targeted towards these important proteins. Ha and na are targeted by abs. Antigenic drift: acquiring point mutations to escape the immune system.
