Microbiology and Immunology 3820A Lecture Notes - Lecture 13: Aureus, Streptokinase, Splenectomy

• School: Western University
• Department: Microbiology and Immunology
• Course: Microbiology and Immunology 3820A
• Professor: David Colby

Document Summary

Coagulase positive enzyme test, positive means staph aureus (almost always), negative means non-staph aureus. Tendency to cause trouble, staph often causes infection. Membrane damaging exotoxins (proteins manufactured by staph and pumped into environment to kill leukocytes): , ,(cid:630),(cid:631) a(cid:374)d leuko(cid:272)idi(cid:374) Superantigen exotoxins: these protein toxins have an affinity for a relatively highly conserved region of the t cell receptor, the mhc class ii complex. James k todd founded when kids had skin and soft tissue infection, septic febrile, low bp. 20% are colonized in genital tract by staph, 5% of those can secrete this toxin. Bacteria churns out toxins by iron and oxygen. Super absorbent rubber chips bound magnesium (divalent cations inhibit toxin production), microfissures keeping toxins. Keeping them in too long, perfect environment for tsst. Food poisoning: enterotoxins a-e and g. Expanded staphylococcal scalded skin syndrome: ritters disease severe, usually fatal, classic scalded skin syndrome, taph(cid:455)lo(cid:272)o(cid:272)(cid:272)al (cid:862)s(cid:272)a(cid:396)let fe(cid:448)e(cid:396)(cid:863, bullous impetigo large blisters.