Microbiology and Immunology 2500A/B Lecture Notes - Lecture 3: Follicular B Helper T Cells, Bone Marrow, Gamma Globulin
31 Jan 2018
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Document Summary
When you have tissue damage, something breaks skin, if virus enters skin what happens. Activated epithelial cells secrete antimicrobials and chemokines to recruit phagocytes to site of infection. Phagocytes resident in tissue: macrophages and dendritic cells immediately start phagocytosing bacteria and viruses. Interferon gets produced: activate nk cell, tell healthy cells in environment to arm selves by producing antiviral enzymes. Some dendritic cells (peripheral) migrate to 2 lt. Always generate both t helper one, and cytotoxic t cell effectors, and effector tfh cells. Swollen glands lots of b and t cells undergoing clonal expansion. Or no b cells and t cells. Consequence: no antibodies, no antiviral protection, no memory.
