Microbiology and Immunology 2500A/B Lecture Notes - Lecture 13: Glycopeptide Antibiotic, Folic Acid, Dna Gyrase
15 Jan 2017
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Document Summary
Applied to inanimate objects (floors, tables, walls) Sufficiently nontoxic - can be applied to living tissue (hand sanitizer) Antibiotics are sufficiently non-toxic for use inside the bodies for higher organisms. Produced by bacteria fungi - exploited by humans. Blood plate test is a classic experiment to test antibiotics. In the plate, there is a ring of inhibition around the disk that contains antibiotics. Enables chemotherapy, organ transplantation, all invasive surgeries, treatment of premature infants. Cancer chemotherapy makes patients immunosuppressed (not specific), thus you need antibodies to prevent infection. Same thing with organ transplant (immunosuppressed to prevent rejection) Scientist are worried that we moved into the post-antibiotic era. Microbial have developed too much resistant to antibiotic and people are not developing new antibiotics. Pharmaceutical companies are not interested in developing new antibiotics. Cost a lot of money to develop antibiotics (need clinical trials, etc). And as soon as the new antibiotic hits the market, microbes develop resistance.
