Biology 3602A/B Lecture Notes - Lecture 28: Parvalbumin, Cardiac Muscle Cell, Skeletal Muscle

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T-tubules are in both skeletal and cardiac muscles. In cardiomyocyte (cardiac muscle cell), not as much sr and sr + t-tubules not as organized. But in skeletal muscle cell: organized network of sr and t-tubules are arranged in specific ways about them. Effect of this: aps arriving down t-tubules has a close association with the part of the muscle cell that is responsible for regulating ca. Left fig: pm going down into t-tubule, with end of motor nerve axon and where the chemical synapse is. So ap is going across pm and diving down into t-tubule. Dhpr is on the t-tubule; they are voltage-gated ca channels. When t-tubule depolarizes like by an ap, dhpr opens. They are associated with ca channels in the sr (right fig); sr ends in big wells full of. Ca, and well on the end is called the terminal cisternae (part of the sr containing a lot of ca and ryr which are also ca channels)

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