Biology 1202B Lecture Notes - Lecture 6: Stop Codon, Start Codon, Eukaryotic Transcription

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A region of dna which is transcribed. Gene transcription is a highly regulated process- genes are only turned on when necessary. The dna alphabet consists of 4 letters: a, t, c, and g. The rna alphabet consists of 4 letters: a, u, c, and g. T in dna, is equivalent to u in rna. Genetic code: the nucleotide information that specifies the amino acid sequence of a polypeptide. Codon: each three letter triplet of the genetic code. These researchers found that short, artificial mrnas of codon length three nucleotides could bind to ribosomes in a test tube and cause a single transfer rna (trna), with its linked amino acid, to bind to the ribosome. Nirenberg and leder then made 64 of the short mrnas, each consisting of a different, single codon. They added the mrnas, one at a time, to a mixture in a test tube containing ribosomes and all the different trnas, each linked to its own amino acid.

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