Biology 1201A Lecture Notes - Lecture 3: Heterozygote Advantage, Sickle-Cell Disease, Reverse Transcriptase

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Variety of phenotype for selection to act on. Adaptation plays catch up, always lags behind. Due to an adaptive trait environment and better suited to survive. Allows the population to better fit in with. Traits that increase the probability that an individual with that trait will survive and reproduce in a given environment. Selection and evolution does not result in perfectly adapted organisms. Selection of traits form what is available. Limitations to what can actually evolve - existing body plan, trade-offs. Selection results in individuals that are "good enough" to survive. Populations are not evolving toward a particular goal or direction. Gaining an advantage in one environment but losing an advantage in another environment. Some variants have arisen from chance by mutation. The drug resistant population survive and reproduce and so the new population is mostly resistant to azt. Reverse transcriptase is slower than in original population. Maintaining variation allows for adaptation to changing conditions or environments with varying conditions.

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