Biology 1201A Lecture Notes - Lecture 8: Indel, Telomerase, Transposase
4 Oct 2017
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Double stranded change= mutation (occurs after 2nd round of replication) During dna replication, polymerase cannot recognize a base, therefore skipping it, which shifts the reading frame: uv radiation: energy is absorbed by pyrimidine rings, altering bonding patterns and forming dimers. Puts kink in backbone and attaches adjacent bases. Oncogene: if something goes wrong with it, it has a potential to cause cancer. Changes in the physical arrangement of genes (or sequences) on chromosomes (cnv-copy number variation). Homologous chromosomes with cnv still act homologous as they still have the same centromere, and are relatively still the same size. You are unique due to the amount of sequences of certain genes you have: insertion/deletion (indel, duplication, reciprocal translocation. Slippage in replication: newly synthesized dna (or template strand) slips, looping out bases. May result in repeat diseases: fragile x (cgg, (untington"s (cid:523)cag(cid:524) Mobile elements dna segments that move within* the genome (used to be called.
