Biology 1002B Lecture Notes - Lecture 19: Antitoxin, Ecdysone, Caspase
30 Mar 2017
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Ced-3 protein is caspase & is inactive until ced-4 activates it. Ced-4 is inhibited by ced-9 which is activated by death signal . Maternal effect genes are the first to be translated. Segmentation genes are the first genes to be expressed in the nuclei of the zygote. Caspases are proteases that cleave specific essential proteins, leading to cell death. Bacterial plasmids: small circular double stranded dna molecules. ( genetic parasites ) Anti-toxin is more quickly degraded by protease. (long lived toxin, short lived anti-toxin) Cells that lose the plasmid are killed by toxin. This mechanism incorporated into eukaryotic cells through endosymbiosis of mitochondria and incorporated into genome through lateral gene transfer. Reaper: gene involved in cell death in drosophila. Under control of hox genes & ecdysone & epigenetic control. Epigenetic regulation persists beyond the conditions under it was originally established. Not a mutation no change in dna sequence. Cell divides activator still present stimulates itself.
