Biology 1001A Lecture Notes - Lecture 4: Reverse Transcriptase, Zoonosis, Central Dogma Of Molecular Biology
19 Feb 2016
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Hiv evolved from a zoonotic disease: it jumped from animals to humans. Hiv is a pandemic because it occurs everywhere on earth. An epidemic is confined to an geographic area. Disobey the central dogma of molecular biology. Store genetic info in rna, reverse transcription into dna. Hiv lifecycle (hijack immune cells: virion (viral particle) enters host cell by fusing and releasing contents into cell cytoplasm, reverse transcriptase enzyme reverse transcribes rna into corresponding dna. 3: transcription, translation, new virions assemble and bud off from host cell and. Integrase splices viral dna into host dna genome enter circulation. The drug azt mimics thymidine (fools rt) Eventually azt stops working though: mutations make a variation in azt-resistance, azt resistance passed from parents to offspring , not all virions reproduce, when azt is present, some forms (azt-resistant) are more likely to reproduce than others (azt-susceptible) Resistance to one drug is inevitable, but resistance to many drugs is less likely.
