Biology 1001A Lecture Notes - Lecture 6: 1000 Genomes Project, Pyrimidine Dimer, Photon
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17 Dec 2017
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Lagging strand- too short- good thing-regulated by telomerase- has own rna polymerase. Telomerase will be active on both ends of a chromosome because on opposite strands on both sides. List of mechanisms to ensure inherence of sameness: During s phase, replication errors can be repaired . Mutation: a double stranded change in dna sequence. Dna damage: other changes to dna not mutation. Proofreading- mismatch: during dna replication polymerase can put in wrong base o. Polymerases need a 3" oh- in the right position on a properly paired base in order to extend polymer. Polymerase 3 recognizes this and activates exonuclease ability (3" to 5") to remove wrong base and repair mismatch is dna damage because not db stranded change. Dna replication evolved to introduce difference into the genome, job is for dna polymerase to make mistakes, maybe purposly give babies slightly different dna o. Maybe its design to introduce mutations in genome and not a mistake.
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