Biology 3338A Lecture Notes - Lecture 24: Neural Tube, Transmembrane Protein, Chordin
9 Jul 2016
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* bmp turns on (other genes in other cells) msx1, a gene that turns on epidermal genes and turns off neural genes. * bmp also turns on xvent1, which makes things more ventral. * on one side we have do (gsc) which turns on the secreted mols, these make dorsal meso. Bmp on the other side makes epidermis through msx and xvent. So you have one side making dorsal and the other side making ventral and dorsal axis is where dorsal wins). So its all about balancing the dorsal and ventral signals. * you make neural cus you inhibit bmp. * in a normal embryo, bmp in general is found everywhere and its inducing ectoderm; using things such as msx1. As the embryos are undergoing cell cleavages, all of the outer layers has bmp in it. * if it wasn"t for gastrulation, you don"t form mesoderm. Bmp differentiating this outer layer from the inside.
