Biology 2581B Lecture Notes - Lecture 10: Haemophilia B, Genomic Library, Replica Plating
28 Apr 2016
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Document Summary
Positional cloning: this is the process of finding the sequence of a gene based on its phenotype. It can be done with (e. g. hemophilia a) or without mapping information (cystic fibrosis). It was found that hemophilia a is often associated with colour-blindness and only found in males. Therefore, it was concluded that the two genes were probably closely linked on the chromosome. Hemophilia b on the other hand was not associated with colour-blindness as often. Therefore, the hemophilia b gene and colour-blindness were not linked. Hemophilia was common in the british royal family beginning with victoria who was a carrier for the gene. As a result, many of the male-descendants had hemophilia. In the old days, hemophilia a was of interest due to the royal families" historical example. Nowadays, hemophilia became of interest because these patients were receiving untested and unscreened clotting factor (prior to 1992) as a therapeutic.
