Biology 2581B Lecture Notes - Lecture 8: Partial Function, Antennapedia, Haploinsufficiency
8 Mar 2016
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You can see this clearly because there are u"s instead of t"s. Every codon on a transcript is read into a protein sequence. Silent mutations: a change in he sequence doesn"t change the amino acid. Wobble position: tolerate different types of nucleotides in that last position. Codons have anywhere from 1 to 6 codons for any particular amino acid. The only unique one is methionine which has one specific codon. Start codon so it has a specific meaning. Missense mutations: exchange one amino acid against another. Severity depends on what substitution it is and where it happens. Conservative mutation: substituted amino acid has chemical properties similar to the one it replaces, then it may have little or no effect on protein function. Nonconservative mutation: amino acids with different properties are likely to have different consequences. Replace one polar amino acid with another polar amino acid. There will be some change but it won"t have a huge effect.
