Biology 2581B Lecture Notes - Lecture 25: Cytochrome C Oxidase Subunit I, Noncoding Dna, Rna Editing
19 Feb 2018
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Cox1: intact&continuous, part of polycistronic transcript, encodes a protein. Lsu & ssu rrna: intact & tandem repeats (head to tail, 300-400 repeats of 5 diff chromosomes. Cox 1 gene fragmented over 9 chromosomes & united @ the rna level to make full transcript. Exhibits rna editing in both cox1 & lsu rrna. World record holder for the highest number of u"s inserted at one site. Frameshift mutations @ aggy (+1) & cccca (+2) motifs @ dna level. Ribosomal slippage ribosomes slip over the frameshift = normal cox 1 gene. Cox1 gene has non-coding sequences (not introns) that persist in mrna. Translational bypass the non-coding shit makes a loop and ribosome jumps over it = normal cox 1. Endosymbiotic gene transfer moved cox1-b into nucleus. In mito, proteins come together to make cox 1. Gene a contains intron which contains gene b. Uses standard genetic code unusual for mitochondria mitochondria do not always use alternative genetic codes.
