Biology 2581B Lecture Notes - Lecture 16: Cpg Site, Human Genome Project, Noncoding Dna

• School: Western University
• Department: Biology
• Course: Biology 2581B
• Professor: David R Smith

Document Summary

Lecture 16: more on encode and genetic modifications. Last time we started at weird ways in which cox1 can be expressed, and then we looked at nuclear genes and their expression. In a genome the genes are the functional bits, and outside of the genes, regulatory elements are functional bits. But this still leaves lots of noncoding dna. We want to know if this noncoding dna has a function --> encode project, tries to answer some of these questions. Human genome project --> annotated all the genes. Encode (later) --> looks at bits of genome outside of the gene and tries to find out if they have a function o. In september 2012 a big nature paper about encode came out, we will summarize the findings. Found that 8. 5% of the genome is involved in transcription factor binding. 75% of the human genome is transcriptionally active --> 75% of the nuclear genome is converted to rna.