Biology 2581B Lecture Notes - Lecture 7: Dna Ligase, Mutagen, Fmr1
14 Mar 2017
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Mutation: genetic change: change in dna sequence, can be inherited, not all are passed on to next generation. Use yeast colonies grown in different medium to track alteration in dna level. Mutant: organism, which experiences a change in dna sequence. Wildtype: (cid:498)normal(cid:499) in population: more frequent, was first. Mutations can be: neutral-no visible effect, few beneficial, problematic changes lethal. Environmental components could determine if mutation is seen (rabbit fur and ice pack: altered appearance, growth condition, behaviours, altered molecules. 2 types of transitions: purine to purine (ga), pyrimidine to pyrimidine (ct: gc at. 4 types of transversions: gc ta, gc cg, at cg, at ta. Movement of base pair(s) over to another place. Mutation can have large changes: affect chromosomes or parts of them, chromosome rearrangements: duplication, deletion insertion, translocation, whole genome duplication. Add penicillin to cells in a test tube, some cells survive: was the mutation present already or did it occur because of penicillin.
