Biology 2382B Lecture Notes - Lecture 10: Muscarinic Acetylcholine Receptor, Cholera Toxin, Bordetella
7 May 2019
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Heart: heart expression muscarinic acetylcholine receptor that binds to acetyl. Associate trimeric via alpha (by removal of gdp-gtp dissociate) *alpha activate effect but rare case b/g subunit bind to k channels. Open, k flows out causing hyperpolarization for contraction (fast acting) Adenylyl cyclase: alpha sub bind to effect (adenylyl) to catalyze production of camp (secondary mess) Stimulatory gprotein mediated by alpha sub: another alpha sub activates ions to inhibit adenylyl. Cholera: disease associated with bad drinking water: drink enters small intestine, bac produce cholera toxin. Epithelial uptake, toxin bind to galpha turns on high levels of camp: camp bind to kinase a, phos cftr (open, release cl) Build up in lumen gets water to enter =diarrhea/dehydration. Pertussis toxin: bordetella toxins: colonize lungs, toxin bind galpha (normally inhibited), activate adenylyl (remove break, stimulatory not high level cause galpha supress when break remove, slow build of camp. Lead to activation of kinase a, phos cftr.
