Biology 2382B Lecture Notes - Lecture 6: Ldl Receptor, Transferrin Receptor, Low-Density Lipoprotein
7 May 2019
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Pinoctyosis: take small amounts of liquid outside of cells. Dynamin protein: get close proximity of 2 membranes, use gtp hydrolysis, help bring membrane together to fuse bud chathrin-coated vesicles cause have cathrin on outside. Low-density lipoprotein (ldl) if builds up cause problems: doesn"t like to float around and bound in ldl particles, cholesterol (found in core) and surrounding is phospholipid monolayer. Ball is polar to interact with aqueous and hydrocarbon chain that interact with inside. Ligand binding arm and b-propeller domain (under acidic becomes protonated) Becomes pos charged, ligand arm is neg (arms drops off and becomes attracted to b-propeller) Target ldl+receptors to clathrin/ap2: apob bind to receptor, specific sorting signal (npxy) is cytoplasmic domain of receptors bind to ap2. Acidification of endosomes/lysosomes: v-class proton pumps: bring protein from cytosol and transport inside but takes energy (need to hydrolyze atp to adp, cl channels: lowers ph inside.
