Biochemistry 3386B Lecture Notes - Lecture 4: Zona Glomerulosa, Zona Reticularis, Adrenal Medulla
15 May 2019
School
Department
Course
Professor
Document Summary
Steroid hormones all steroids are made from cholesterol: all steroids are made from cholesterol w 27 carbon atoms, corticosteroids and mineralocorticoids have 21 carbon atoms and androgens have 19 carbons, cortisol: the major glucocorticoid) Its production is controlled by the pituitary via acth secretion. It"s normally measured in its sulfates form, so the lab refers to the test as the. Biosynthesis of the hormones of the adrenal cortex (adrenal steroids: don"t have to memorize, a side chain degrading enzyme (i) converts cholesterol to pregnenolone, then 3-b-oh dehydrogenase (ii) adds an oh radical to the 17-carbon position to make. 17-oh hydroxypregnenalone and 17-oh progesterone: both progesterone and 17-hydroxyprogesterone can be substrates for the 21 hydoxylation enzyme (iii, the products forms are 11-deoxycorticosterone and 11-deoxycortisol, respectively. Acth = adrenocorticotropic hormone: atch stimulates cortisol production, cortisol has negative feedback, cortisol stress, can be acute stress like hypoglycemia, can be chronic like physical or emotional stress.
