Biochemistry 2280A Lecture Notes - Lecture 18: Gibbs Free Energy, Hydrolysis, Pyrophosphate

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20 Jan 2020

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G vs. g : g gibb"s free energy, g gibb"s free energy at standard conditions, constant pressure and concentration at standard conditions. Note: spontaneity does not tell you anything about the rate of the rxn; just because a rxn is spontaneous, it does not mean it"s fast. Irreversible rxns: for reactions far from equilibrium, g is a large +ve or -ve value, and the reaction is said to be irreversible, products are strongly favoured. Irreversible rxns are insensitive to changes in concentration. Ways to regulate an irreversible reaction: change the amount of enzyme. Increasing the amount of enzyme increases the rate of the forward rxn substantially: can be done by changing the rate of transcription/translation, or degrading the enzyme, long-term processes; can take hours/days, change the location of enzyme. 3: allosteric enzyme regulation, allosteric = other solid or other shape , this can increase or decrease enzyme activity, the enzyme does not follow michaelis-menten kinetics when inhibited.

Related Questions

Which of the following statements about Gibbs Free Energy is not true?

Question 12 options:

	A) The reaction with a lower Gibbs Free Energy has a greater rate constant.
	B) A negative value for the Gibbs Free Energy of a reaction determines that the reaction is spontaneous.
	C) A Gibbs Free Energy of zero means the reaction is at equilibrium.
	D) The Standard Gibbs Free Energy of a reaction can be calculated from the Standard Enthalpies and Standard Entropies of the reactants and products.

1) A reaction has ÎHârxn= -116 kJ and ÎSârxn= 324 J/K .

At what temperature is the change in entropy for the reaction equal to the change in entropy for the surroundings? Express your answer in kelvins.

2) Consider the following reaction:

2Ca(s)+O2(g) â 2CaO(s)

ÎHârxn= -1269.8 kJ; ÎSârxn= -364.6 J/K

Assume that all reactants and products are in their standard states.

Calculate the free energy change for the reaction at 19 âC.

Express your answer using four significant figures.

3) Consider the following isomerization reactions of some simple sugars and values for their standard Gibbs free energy ÎGâ:

reaction
reaction A: glucose-1-phosphateâ¶glucose-6-phosphate ÎGâ=â7.28 kJ/mol
reaction B: fructose-6-phosphateâ¶glucose-6-phosphate, ÎGâ=â1.67 kJ/mol
Calculate ÎGâ for the isomerization of glucose-1-phosphate to fructose-6-phosphate.
Express your answer with the appropriate units.

Please answer the following question and show all necessary workto receive credit:

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Biochemistry 2280A Lecture Notes - Lecture 18: Gibbs Free Energy, Hydrolysis, Pyrophosphate

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