Biochemistry 2280A Lecture Notes - Lecture 11: Coenzyme Q10, Electron Affinity, Reduction Potential

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Energy flow from electron carriers to atp. Stoichiometry of proton movement and atp synthesis. It becomes part of newly formed h2o. Can be both a metal ion or a co-enzyme. Pretty much never dissociated from the enzyme. Goal is to make a electrochemical gradient. Move protons from the matrix to the intermembrane space. So that you can use the gradient to make energy. The higher the redox potential the more the molecule wants electrons. Oxygen has the highest redox potential, thus it has the highest affinity for electrons. Electrons are passed to carriers with higher redox potential. In order of redox potential (electron affinity) Flavin < iron-sulfur centres < ubiquinone < cytochromes < copper centers. Sometimes the strength of the electron affinity order can change (due to protonation/deprotonation/ph/pka changes: flavin - isoalloxazine ring. Usually always bound to a protein (prosthetic group) Not like nadh which can be free. Picks up 2 electrons (carries them from place to place)

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