PSY407H1 Lecture Notes - Lecture 3: Dopamine Receptor D1, Alcohol Dehydrogenase, Cyp2A6
Document Summary
For the genetic portions of addiction to reveal themselves, you need to try the drug. Theory of common liability means that if you ave a history of addiction to alcohol, you are more likely to get addicted in general, not necessarily to alcohol. Interplay of environment and genetics is very strong predictor. I(cid:374) the e(cid:454)pe(cid:396)i(cid:373)e(cid:374)tal phase, it"s very hea(cid:448)il(cid:455) i(cid:374)flue(cid:374)(cid:272)ed (cid:271)(cid:455) the e(cid:374)(cid:448)i(cid:396)o(cid:374)(cid:373)e(cid:374)t: as drug use continues even into the treatment phase, the environments role diminishes and is replaced by a much stronger role of genetics. Dopamine d1 receptor is very important: certain polymorphisms of dopamine genes have been associated with drug addiction and related factors that either worsen addiction or increase likelihood. Genetics influence your bodies ability to process the drug: bioa(cid:448)aila(cid:271)ilit(cid:455) a(cid:374)d it"s a(cid:272)ti(cid:448)e (cid:373)eta(cid:271)olites, also impacts differences in the proteins or receptors at which the drug acts. Alcohol dehydrogenase & alcohol dependence: alcohol dehydrogenase is what breaks down the first product of alcohol.
