PSL301H1 Lecture Notes - Lecture 22: Proximal Tubule, Epithelial Sodium Channel, Furosemide
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PSL301H1 Full Course Notes
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Tubules they reabsorb solute & water and/or secrete solute so that despite what we eat/drink, our body composition and volumes remains normal. Filtration of water: filtrate gets filtered in bowman"s capsule and travels down the tubule, much of that water gets reabsorbed, 99% of water is retained (even through 20% of water is filtered) Filtration of sodium recall, if solute is reabsorbed, water will follow to equilibrate [solute: na+/k+ atpase is found only in the basal side pumps na+ out of the cell. Inhibited by diuretic group thiazides: collecting duct, critical place where the amount of water and sodium excreted is regulated, epithelial sodium channel (enac, no aquaporin channels unless the cells recognize vasopressin.
