PSL301H1 Lecture Notes - Lecture 1: Oncotic Pressure, Membrane Transport Protein, Platelet
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PSL301H1 Full Course Notes
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Plasma proteins: generate colloid osmotic pressure (higher than interstitium), buffer ph most made in liver, 7% of plasma content. Albumin: maintains colloid osmotic pressure, carrier (60% plasma proteins) Globulin : clotting factor, enzyme, carrier, antibody (35% plasma proteins) Fibrinogen: cleaved to form fibrin in blood clotting (4% plasma proteins) Lecture 1: blood: transports gases, nutrients, hormones, metabolic wastes, regulates composition of interstitial fluid i. e. ph, ions, water, etc, regulates temperature by absorbing/redistributing heat (vasoconstriction/vasodilation, 5l in male, 4l in female, 46-63% plasma, 37-54% formed elements. Hematocrit: % total blood volume occupied by packed (centrifuged) rbcs, normal = 37-54% Mean corpuscular volume: average volume of 1 rbc. Mean corpuscular hemoglobin: amount of hemoglobin per rbc. Mean corpuscular hemoglobin concentration: amount of hemoglobin per volume of 1 rbc. Plasma: 92% water, 8% ions, aas/proteins/glucose/lipids/n2 waste, elements/vitamins, gases. Hemoglobin: heme group liked covalently to globin protein, holds 4 o2: 12-17 g per dl blood.
