PSL301H1 Lecture Notes - Lecture 19: Phrenic Nerve, Hypoventilation, Motor Neuron
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PSL301H1 Full Course Notes
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Common pathway for control: generating respiratory rhythm, factors that affect breathing, phox2b and ccvh. Breathes on own during the day, but needs ventilator when sleeping (trachea tube) - odine"s curse. Mutation in phoxb2 gene, codes for transcription factor. This gene is critical for dev of autonomic neurons. Presents with alveolar hypoventilation during sleep and often during wakefulness. Altered respiratory control incl reduced or absent ventilatory responses to hypercarbia (inc co2) and hypoxemia (dec o2) Under control of motor neurons - inspiration and expiration. Phrenic nerve that controls the diaphragm originates from cervical regions: c3, c4, c5. These are phrenic motoneurons that compose the phrenic nerve. Motor neurons that innervate the intercostals come from spinal segments t1 to t12. Key place for rhythmic activity of neurons is controlled by pre-motor neurons in medulla. Two phrenic nerves that innervates both sides of the diaphragm. For inspiration, activity is in the phrenic nerve, but no activity in expiration.
