PSL201Y1 Lecture Notes - Lecture 35: Lactic Acidosis, Respiratory Acidosis, Metabolic Acidosis
Document Summary
Lactic acid produced during severe anerobic condition or exercise to point of exhaustion or severe disease that impedes blood flow to disease. 3 defense against acid-base disturbances in body buffering of h+ ions , respiratory compensation and renal compensation. Most important ecf buffer is bicarbonate large amount by metabolic co2 create most important ecf of body. 3 icf buffers that play a role in acid base balances proteins more concentrated than bicarbonate or phosphate buffers especially in icf, protein buffering system accounts for about. Co2 combining with h2o and in process releasing hco3- and h+ in tissues. Respiratory compensations second line of defense: takes minutes to have effect regulates ph by varying ventilation (frequency or depth): increase ventilation=decreases co2 , decrease ventilation=increases co2. When ph falls and increased in h+ concentration and detected by peripheral chemoreceptors in carotid arch these peripheral chemoreceptors respond by increasing ventilation and blowing off extra co2 and releasing pco2 levels and increasing plasma ph.
