PHC320H1 Lecture : A success story
Document Summary
All blood cells arise from one kind of multipotent stem cell e. g. multipotent hemopoietic stem cell progenitor lymphoid or myeloid progenitor. Type of leukemia depends on defects of specific progenitors. Cancer cells: stem cells/daughter cells fail to differentiation. Leukemia: cancer of blood/bone marrow characterized by abnormal proliferation of blood cells (usually wbcs, leukocytes) Chronic myeloid leukemia (cml: myeloproliferative disorder, median age 53, nonspecific symptoms, hard to detect, massive clonal proliferation of myeloid cells, biphasic: chronic (stable) phase blast phase. Philadelphia chromosome: cml patients have characteristic chromosomal abnormality t(9;22, not present in patient"s normal cells. Acquired genetic abnormality: genetic abnormality causally associated with cml, reciprocal translocation between chromosome 9 and 22, abl chr9, bcr chr 22, fused together, bcr-abl constitutively active tyrosine kinase (fusion gene, abl is a tyrosine kinase. When translocated, it is constitutively active: blast crisis: cml cells acquire secondary genetic abnormalities in addition to.