PCL302H1 Lecture 1: Lecture 1 - Introduction to Pharmacodynamics.pdf
28 Sep 2014
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Topics: the evolving concept of a receptor, receptor theory, key advances leading to modern drug discovery. What is a receptor: biological component to which a drug binds with high affinity to produce an effect, mostly cell surface proteins (e. g. gpcrs) but also other types of molecules (e. g. enzymes) Katzung, b. g. , masters, s. b. and trevor, a. j. (2011). Pharmacodynamics studies: understand the actions of a drug, define interactions between drugs and target tissues, understand the scope of drug effects, facilitate rational design of superior drugs. Receptor concept predated knowledge of the receptors as molecules. The concept of a drug target: the action of a drug involves the interaction with a specific target. The goal is to find chemical substances that have special affinities for pathogenic organisms and that, like magic bullets, go straight to their targets . The method of discovering this drug is the corner stone of modern drug discovery!
