PCL102H1 Lecture Notes - Proopiomelanocortin, Solomon H. Snyder, Enkephalin
Document Summary
Read : kalant: text chapter (book of readings); snyder stalking the opiate receptor ; Read for the next lecture: carmichael et al. Dept text chapter (book of readings); read for the next section carlson, p. 3-9. These are the analgesics for moderate / severe pain. They are all we have for moderate / severe pain: the opioid drugs. Usage: opiate analgesics, opioid analgesics, opiate suggests it comes from poopy; morphine and codeine, synthetic drugs that weren"t derived from the opiates bind to the same receptor and do the same thing though, narcotic analgesics . This is because people get addicted to them. : opium (dried poppy sap from seed pod; turkey or greece) ; liquid extraction: paragoric was used for dhierrea. The opiods and opiates all decrease motility in the g. i. tract. Semisynthetic: heroin late 19th centrury; was supposed to be non-addicting. Pure synthetics: meperidine first pure synthetic does not constrict pupils (only one, methadone, etc. , etc.
