KPE162H1 Lecture Notes - Lecture 12: Louis Pasteur, Intracellular Parasite, Infection
2 Apr 2019
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Microbiology: anthony van leeunwenhoek invented the microscope in 1674, he discovered algae, protozoa, sperm cells, this started the science of microbiology. Theories of infection: many researchers noted the presence of microorganisms in people with disease, theory of spontaneous germination of germs wrong, germs don"t just appear, louis pasteur disproved this in 1864 demonstrated transmission. Micro-organisms: unicellular, bacteria, atypical bacteria, protozoa, multicellular, fungi, subcellular, viruses, prions (not really organisms, infectious proteins) Viruses: nucleic acid core, dna or rna, protein envelope enclosing core, parts of it sticks out like spikes for cell recognition/attachment, has info for reproduction, no machinery to do it needs a host cell. Prions: mutant versions of a protein (prpc) found on surface of mammalian neurons, transmissible ( infectious ) disease agents, can get it if you eat another"s nervous system. Bacteria: prokaryotes (cells with no nuclei, cell walls, dna is loose inside the cell, replicate by mitosis, aerobes/anaerobes.
