HMB450H1 Lecture Notes - Lecture 8: Congenital Hypothyroidism, Neural Development, Hypothyroidism

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T4 and t3 bind with integrin receptor and signal to a tr-alpha in the cytoplasm to polymerize actin and synthesize microtubules. Important in growth cone development and structural changes in spines: impaired neurite growth and migration: abnormal neuronal migration in developmental hypothyroidism and hypothyroxinemia. Congenital hypothyroidism: 1 in 4000 newborn babies severe thyroid deficiency, severe congenital hypothyroidism can lead to growth failure and permanent id, developed world performs newborn screening for hypo-th. In developed countries most, common causes of ch: maternal hypothyroidism, underdeveloped thyroid (premature, thyroid dysfunction, fetal alcohol syndrome, there are also other thyroid hormone disorders such as iodine deficiency, and transient hypothryoxemia. Paper: discussion: changes in ct thickness: these findings maybe attributed to the abnormal cortical migration patterns as some neurons ended up elsewhere then they were destined to be. For example, their findings of bilateral cortical thinning in middle and superior frontal regions may explain ch weaknesses on wm tasks.

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