HMB300H1 Lecture 2: Lecture 2 – Learning and Memory.pdf
Document Summary
Lecture 2 learning and memory. Advantages of simpler systems provided a model system as integral parts of neuroscience. Memory is stored in brain, but we cannot read back on it ex. Like access to a usb key don"t know how we retrieve memories. Kandel has to use reductionist approach studied simplified model organism systems. Eric kandel and his collaborators used aplysia to unravel synaptic mechanisms for different forms of learning and memory. Identifying where and how different types of information are stored: how things can be strengthened and weakened. Hebbian theory: memory results from strengthened synaptic modification. Neurons that fire together, wire together . Electrical stimulation of brain: experimentally produce measurable synaptic alterations - dissect mechanisms, non- associative learning. Lowered response to same stimulus applied repetitively. Learning to intensify response to stimuli organism gets habituated and stops responding procedural memories. Review of simple procedural learning.
