HMB200H1 Lecture Notes - Lecture 6: Mcgill University Health Centre, Donald O. Hebb, Synaptic Plasticity
Document Summary
Experience alters the brain"s organization and neuroplasticity is required for development, learning and memory functions as well as for survival: plasticity, therefore, should be measureable, as changes in brain structure and/or synaptic connections. Not my behavior to yours but my behavior to by behavior yesterday. Synaptic signaling can be remarkably consistent (given the same stimulus: for a given stimulus (eg. injecting positive charges into axon) = same frequency of action potentials (remember rate law) And it can also change in either direction change = plasticity: but: some stimuli (eg. with specific timing) Different level of response (eg. amplitude of (e) of (i) psps: given the same initial stimulus as before but right after = larger epsp. First discovery of synaptic plasticity in mammals: hippocampus (of rabbits) Long-lasting potentiation of synaptic transmission in the denate area of the anaesthetized rabbit flowing stimulation of the perforant path: sliced rabbit"s hippocampus (known for important area for learning and memory and structurally simplest)
