EEB325H1 Lecture 9: Lecture 9 Cancer and Chemotherapy
9 Feb 2017
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Document Summary
Need 6 of these hallmarks to get cancer: many combinations available. Radiation- along with drug works by disrupting cell division (shredding dna as replication is happening) Some cells replication slowly and infrequently like liver cells. Some cells divide frequently like hair cells, skin, Some cells divide really frequently- tumour cells. Radiation or chemotherapy aimed at tumour cells because they divide more frequently: this is why hairloss is common during chemo- chemo bad for you, but worse for tumour. Growth promtion- mutations in oncogenes induce cells to divide continuously. Tumour suppression- mutations in ts genes lead to the growth of altered cells no longer being prevented. Her2 is a receptors overexpressed in 20% of breast cancer, so more cell growth, Herceptin binds to her2 and blocks it: less than 35% of patients initially respond to treatment, 70% of those that did response, progressed to metastatic cancer within a year- way around the pathway and resistance is a problem.
