BCH311H1 Lecture 1: Nucleic Acid Structure
158 views5 pages
12 Jan 2019
School
Department
Course
Professor
Document Summary
Bch311h1s lec01-nucleic acid structure: tetranucleotide hypothesis: levene/tipson, single-stranded dna structure: astbury/bell, discovery of h-bonds (gullard) Base tautomers: enol form is a h-bond donor. Triple-helix structure with phosphate backbone inside (completely wrong: chargaff. A:t = 1:1: dna double helix (watson, crick, wilkin, franklin) Bch311h1s lec01-nucleic acid structure: forces that stabilize dna structure, hydrogen bonding. Canonical watson-crick base pairs: sugars are far apart. Hoogsten base pair: sugars are closer to each other, guanine h bonding in telomere, guanines h-bonding with themselves forming a g-quadruplex. Wobble base pairs: u and g don"t usually base pair, but if they come into the right orientation, they will base pair. Melting temperature (tm) reflect dna stability: tm = half of the sample is dsdna and half is ss dna. Dipole interaction between stacked bases stabilized dna structure. Also affect tm less dipole effect less energy needs to separate strands, tm decreases.
Get access
Grade+
$40 USD/m
Billed monthly
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
10 Verified Answers
Class+
$30 USD/m
Billed monthly
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
7 Verified Answers
Related textbook solutions
Chemistry: Structure and Properties
2 Edition,
Tro
ISBN: 9780134293936
Basic Chemistry
5 Edition,
Timberlake
ISBN: 9780134138046
Principles of Chemistry Molecular Approach
4th Edition,
Tro
ISBN: 9780134112831
Principles of Chemistry Molecular Approach
3rd Edition, 2014
Tro
ISBN: 9780321971944
Chemistry: Structure and Properties
2nd Edition,
Tro
ISBN: 9780134293936
Chemistry: A Molecular Approach
3rd Edition,
Tro
ISBN: 9780321809247
Chemistry: A Molecular Approach
5th Edition,
Tro
ISBN: 9780134874371
Principles of Chemistry: A Molecular Approach
4th Edition,
Tro
ISBN: 9780134895741
Chemistry: The Central Science
14th Edition, 2017
Brown
ISBN: 9780134414232